Emma Rogerson (a), Dr. Vett Lloyd (a), Dr. Gupreet Singh-Ranger (a,b) and Krystal Schimp-Manuel (b)
(a) Mount Allison University
(b) Upper River Valley Hospital, Horizon Health Network
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in Canada. It is heterogenous in development and presentation, therefore, treatment strategies must be personalized for each CRC patient. It is important to understand the value that each prognostic factor of CRC provides in estimating prognosis. In this study, a retrospective chart review was conducted at a single institution located in New Brunswick, Canada, in order to evaluate the demographic, clinical and pathologic prognostic factors and their influence on patient outcome in terms of overall survival (OS) and reoccurrence free survival (RFS) for CRC patients (n = 60). Kaplan Meier survival curves were constructed for each of the prognostic factors assessed. The log-rank test was used to determine if there was a statistically significant difference in OS and RFS for each of the patient groups within each prognostic factor. This study showed that for the relatively small sample of patients, the strongest prognostic factors for overall survival was histologic grade of the tumour, whilst the strongest prognostic factors for reoccurrence free survival were age at diagnosis, distal resection margin and circumferential resection margin. Because there is no central database of CRC patient outcome after surgery in the province of New Brunswick, our study may point to areas where further investigation is needed. In the future, we hope this will provide a foundation for a larger survival analysis that will increase knowledge on OS and RFS, allowing for more successful CRC patient outcome in New Brunswick.